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Aduro Biotech Provides Business Update and Reports Second Quarter 2020 Financial Results
703彩票135345cc

August 3, 2020 at 4:05 PM EDT

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  • Announced definitive merger agreement with Chinook Therapeutics, which is expected to close in the second half of 2020, subject to the satisfaction or waiver of the conditions to completion of the merger. Following completion of the merger, the combined company will operate as Chinook Therapeutics and advance a pipeline of precision medicines for kidney diseases, led by atrasentan and BION-1301 in IgAN, assuming satisfaction of the conditions to closing the merger.
     
  • Presented healthy volunteer data from Part 1 (single ascending dose) and Part 2 (multiple ascending dose) of the ongoing Phase 1 study of BION-1301 at the 57th ERA-EDTA Virtual Congress.
     
  • Presented nonclinical toxicology studies of BION-1301 evaluating intravenous administration for up to six months and subcutaneous administration for up to one month at the 57th ERA-EDTA Virtual Congress.
     
  • Dosed the first patient with IgAN in Part 3 of the ongoing Phase 1 study of BION-1301.

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  • Cash Position  Cash, cash equivalents and marketable securities totaled $186.1 millionatJune 30, 2020, compared to $213.6 millionatDecember 31, 2019. Cash spend year to date was offset by the receipt of a $10 million development milestone payment from Merck in the first quarter of 2020.
     
  • Revenue – Revenue was $5.6 million for the second quarter of 2020 and $19.5 million for the six months ended June 30, 2020, compared to $4.9 millionand$8.8 million, respectively for the same periods in 2019. The increase in revenue for the quarter was primarily due to fluctuations in revenue recognized under our Novartis collaboration which is dependent on clinical timelines and progress under the research and collaboration agreement. In addition to the Novartis collaboration, the increase in revenue for the year to date period included the recognition of the $10.0 million development milestone payment received under our license and research collaboration agreement with Merck. 
     
  • Expenses –
    • Research and development expenses were $11.1 million for the second quarter of 2020 and $26.9 million for the six months ended June 30, 2020, compared to $16.7 millionand$34.2 million, respectively, for the same periods in 2019. The decrease in expense from 2019 to 2020 was primarily due to 2019 costs related to the deprioritized programs that were substantially wound down in 2019 offset by higher costs for our

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      618彩票合法今年三季度末,大型銀行、股份制銀行資本充足率均較二季度末出現上升,而城、農商行資本充足率均較二季度末下滑0.12個百分點,可以看到,中小銀行資本補充壓力相對其他銀行更大  厄爾尼諾-南方濤動現象  農產品在種植階段最為擔憂的因素之一便是天氣異常所造成的減產,這里涉及到不合時宜的氣溫、降水、風力等等,其中關注最多的氣象問題為厄爾尼諾-南方濤動(ENSO)影響

        Three Months Ended June 30,  Six Months Ended June 30, 
        2020  2019  2020  2019 
      Revenue:                
      Collaboration and license revenue $5,574  $4,888  $19,524  $8,826 
      Total revenue  5,574   4,888   19,524   8,826 
      Operating expenses:                
      Research and development(1)  11,108   16,657   26,936   34,151 
      General and administrative(1)  9,284   7,832   17,103   16,056 
      Restructuring and related expense  2,046   367   6,354   3,361 
      Amortization of intangible assets  136   139   272   279 
      Total operating expenses  22,574   24,995   50,665   53,847 
      Loss from operations  (17,000)  (20,107)  (31,141)  (45,021)
      Interest income  413   1,497   1,333   2,968 
      Other expense, net  (28)  (3)  (47)  (22)
      Total other income  385   1,494   1,286   2,946 
      Loss before income tax  (16,615)  (18,613)  (29,855)  (42,075)
      Income tax benefit     35   5,665   70 
      Net loss $(16,615) $(18,578) $(24,190) $(42,005)
      Net loss per common share, basic and diluted $(0.21) $(0.23) $(0.30) $(0.53)
      Shares used in computing net loss per common
        share, basic and diluted
        80,862,621   80,032,022   80,810,211   79,847,960 
                       
      (1) Includes the following share-based compensation expenses:                
      Research and development  1,363   1,713   2,226   3,746 
      General and administrative  1,665   1,623   2,837   3,293 

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        June 30,  December 31, 
        2020  2019 
      Assets        
      Current assets:        
      Cash and cash equivalents $71,103  $59,624 
      Marketable securities  100,028   153,978 
      Accounts receivable  1,169   342 
      Income tax receivable  5,665    
      Prepaid expenses and other current assets  3,015   3,958 
      Total current assets  180,980   217,902 
      Marketable securities  14,995    
      Property and equipment, net  21,706   24,688 
      Operating lease right-of-use assets  20,334   21,110 
      Goodwill  8,177   8,167 
      Intangible assets, net  18,723   18,978 
      Restricted cash  468   468 
      Total assets $265,383  $291,313 
      Liabilities and StockholdersEquity        
      Current liabilities:        
      Accounts payable $1,339  $414 
      Accrued clinical trial and manufacturing expenses  2,615   4,253 
      Accrued expenses and other liabilities  9,673   8,181 
      Operating lease liabilities  1,741   1,803 
      Deferred revenue  4,935   6,950 
      Total current liabilities  20,303   21,601 
      Contingent consideration  2,013   1,051 
      Deferred revenue  161,312   166,963 
      Deferred tax liabilities  3,531   3,527 
      Operating lease liabilities  30,855   31,636 
      Other long-term liabilities  753   940 
      Total liabilities  218,767   225,718 
      Commitments and contingencies        
      Stockholders’ equity:        
      Preferred stock      
      Common stock  8   8 
      Additional paid-in capital  557,263   552,077 
      Accumulated other comprehensive income  439   414 
      Accumulated deficit  (511,094)  (486,904)
      Total stockholders’ equity  46,616   65,595 
      Total liabilities and stockholders’ equity $265,383  $291,313 

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      618彩票官网app下载  其實不論是否有拉尼娜/厄爾尼諾,大豆在種植階段天氣都是敏感因素,不合時宜的降雨、高溫、干旱等等,均會對盤面產生影響,但從天氣圖形觀測到的數據傳導到實際種植階段,是否產生影響及產生多大影響又很難界定,阿根廷很難做到如美國對大豆每個階段的優良率和種植情況均有及時反饋,因此交易天氣本身便存在很多的主觀性和不確定性  在JS016產品的研發進展方面,君實生物表示,根據www.clinicaltrials.gov公示信息,美國禮來制藥停止的ACTIV-3臨床試驗是一項在COVID-19患者中開展的評估LY-CoV555聯合標準治療(瑞德西韋)對比安慰劑聯合標準治療(瑞德西韋)的III期臨床試驗,該研究不涉及公司產品JS016,只涉及禮來制藥的另一個中和抗體LY-CoV555

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      703彩票135345cc

      703彩票135345cc

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